Objective: To evaluate the efficacy, safety, and clinical impact of blinatumomab across the treatment continuum of B-cell acute lymphoblastic leukemia. Design: Systematic evidence synthesis of randomi

Objective: To evaluate efficacy, durability, and safety of next-generation chimeric antigen receptor T-cell therapies in relapsed or refractory acute lymphoblastic leukemia. Design: A systematic revie

Background: Oestrogen and oestrogen-modulating therapies remain central to women’s health, yet their associations with cancer, cardiovascular outcomes, and fibroid disease continue to be debated. The

Background: Lens-induced glaucoma (LIG) is still a major cause of irreversible blindness in developing countries, largely because of delayed treatment and diagnosis. Although surgery is largely succes

Background: Salpingectomy, once used for sterilization or ectopic pregnancy, has been explored more and more as a preventive strategy for ovarian cancer. Its oncologic value, surgical acceptability, r

Background: Buccal mucosal graft urethroplasty (BMGU) is now the gold standard in the treatment of anterior urethral strictures, particularly of long lengths or recurrences. But heterogeneity of outco

Background: Scabies, a parasitic skin infestation caused by Sarcoptes scabiei, remains a significant public health challenge globally, particularly in resource-limited settings and vulnerable populati

Background: The Fine Needle Aspiration Cytology (FNAC) and Tru-Cut Biopsy (TCB) are significant investigative techniques used to differentiate breast issues. There is much research done on how well th

Background: Laparoscopic surgery has become a novel approach for numerous surgical interventions. This is because of its minimally invasive nature. However, it has found to be correlated with certain