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Annals of Medicine and Medical Sciences
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  3. Digital Gangrene as Initial Manifestation of Anti-Phospholipid Antibod…
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Digital Gangrene as Initial Manifestation of Anti-Phospholipid Antibody Syndrome: A Case Series

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Annals of Medicine and Medical SciencesVolume 04 (2025), Version 1 February 20, 2025pp. 38 - 40
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Abstract

Early manifestation of Antiphospholipid Syndrome (APS), include Dermatological features which aid in early diagnosis, before occurrence of any life threatening complications. However, digital gangrene is rare skin phenomenon in APS and even rarer as initial presenting feature of APS. So we herein report a series of three cases of APS, including one case of primary APS in young female, whose was occurrence of with digital gangrene as first manifestation of the disease.

References
  1. [1] Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemos 2006; 4: 295-306.
  2. [2] Francés C, Niang S, Laffitte E, le Pelletier F, Costedoat N, Piette JC. Dermatologic Manifestations of the antiphospholipid syndrome: Two Hundred Consecutive Cases. Arthritis Rheum 2005; 52: 1785-1793.
  3. [3] Roche SW, Niriella DC, O'Mahoney A, Cayley ACD. The anti-phospholipid antibody syndrome in a 77 year old man with digital gangrene. Postgraduate Medical Journal 1989; 65: 837- 839.
  4. [4] Petri M. Epidemiology of the antiphospholipid antibody syndrome. J autoimmune 2000; 15: 145-151.
  5. [5] Vianna JL, Khamastha MA, Ordi-Ros J, Font J, Cervera R, Lopez-Soto A, et al. Comparison of the primary and secondary antiphospholipid syndrome: a European Multicenter Study of 114 patients. Am J Med 1994; 96: 3-9.
  6. [6] Rai R, Sekar CS, Kumaresan M. Antiphospholipid syndrome in dermatology: An update. Indian J Dermatol Venerol Leprol 2010; 76: 116-124.
  7. [7] Gibson GE, Daniel Su WP, Pittelkow MP. Antiphospholipid syndrome and the skin. J Am Acad Dermatol 1997; 36: 970-982.
  8. [8] Algre VA, Gastineau DA, Winkelmann RK. Skin lesions associated with circulating lupus anticoagulant. Br J Dermatol 1989; 120: 419-429
  9. [9] Asherson RA, Frances C, Iaccarino L, Khamashta MA, Malacarne F, Piette JC, et al. The antiphospholipid antibody syndrome: diagnosis, skin manifestations and current therapy. Clin Exp Rheumatol 2006; 24: S46-S51.